000			04405nam a22004815i 4500
999			_c2251 _d2251
001			978-3-319-54064-1
003			DE-He213
005			20200805155321.0
007			cr nn 008mamaa
008			170602s2017 gw | s |||| 0|eng d
020			_a9783319540641 (ebook)
020			_a9783319540627
024	7		_a10.1007/978-3-319-54064-1 _2doi
040			_aSpringer Nature Metadata _beng _cMIU _dMIU_ain
050		4	_aQH367.5 _b.P49 2017
100	1		_aBleidorn, Christoph. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aPhylogenomics : _bAn Introduction / _cby Christoph Bleidorn.
250			_a1st ed. 2017.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aXIII, 222 p. 89 illus., 87 illus. in color. _bonline resource.
505	0		_a1. Genomes -- 01.1 Prokaryotes vs. Eukaryotes -- 01.2 Genome Structure -- 01.3 Genome Sizes -- 01.4 Human Genome and Ancient DNA (Neandertaler, Denisova) -- 2. Genomes of Organelles -- 02.1 Mitochondria -- 02.2 Plastids -- 02.3 Outlook Obligate Endosymbionts -- 3. Transcriptomes -- 03.1 mRNA -- 03.2 Transcripts -- 03.3 Expression Level -- 03.4 Alternative Splicing -- 4. Sequencing Techniques -- 04.1 Sanger -- 04.2 Illumina -- 04.3 454 -- 04.4 PacBio -- 04.5 Outlook Nanopore Sequencing -- 5. Genome Sequencing Strategies -- 05.1 Whole Genome Shotgun -- 05.2 RADseq -- 05.3 Target Enrichment -- 05.4 RNAseq -- 6. Assembly and Mapping -- 06.1 Assembling Strategies (kmer vs OLC) -- 06.2 Data Quality and Filtering -- 06.3 Re-Sequencing and Mapping -- 06.4 De novo Assembly Genome -- 06.5 De novo Assembly Transcriptome -- 7. Locating Genes -- 07.1 Orthology vs. Paralogy -- 07.2 BLAST and Successors -- 07.3 Hidden Markov Profile -- 07.4 Ortholog Conjecture -- 8. Alignment -- 08.1 Alignment Strategies -- 08.2 Alignment Masking -- 9. Phylogenetic Analysis -- 09.1 Distance Measurements -- 09.2 Maximum Parsimony -- 09.3 Maximum Likelihood -- 09.4 Bayesian Inference -- 09.5 Supermatrix vs. Single Gene Analysis (Gene Trees vs. Species Trees) -- 10. Systematic Errors in phylogenetic Analysis -- 10.1 Prediction: Evolutionary Models -- 10.2 Heterogenity Nucleotide/Amino Acid-Composition -- 10.3 Variation of substitution rate between the lines -- 10.4 Variation of substitution rate over time -- 10.5 New Approaches to Correct systematic Errors -- 11. Genome-wide Characteristics -- 11.1 Gene Order -- 11.2 Mobile Elements -- 11.3 microRNAs -- 11.4 Differences in the genetic code -- 12. Index -- 13. References.
520			_aThis unique textbook provides a clear and concise overview of the key principles of the complex field of phylogenomics, with a particular focus on sequencing technologies that are crucial to studying and understanding interrelations in evolutionary genomics. It includes chapters dedicated to the analysis of nucleotide sequences using assembling and alignment methods and also discusses the main strategies for phylogenetic studies, systematic errors and their correction. This highly readable textbook is intended for graduate students and young researchers with an interest in phylogenetics and evolutionary developmental biology.
650		0	_aEvolutionary biology.
650		0	_aHuman genetics.
650		0	_aBioinformatics.
650		0	_aMicrobial genetics.
650		0	_aMicrobial genomics.
650		0	_aAnimal genetics.
650	1	4	_aEvolutionary Biology. _0https://scigraph.springernature.com/ontologies/product-market-codes/L21001
650	2	4	_aHuman Genetics. _0https://scigraph.springernature.com/ontologies/product-market-codes/B12008
650	2	4	_aBioinformatics. _0https://scigraph.springernature.com/ontologies/product-market-codes/L15001
650	2	4	_aMicrobial Genetics and Genomics. _0https://scigraph.springernature.com/ontologies/product-market-codes/L32010
650	2	4	_aAnimal Genetics and Genomics. _0https://scigraph.springernature.com/ontologies/product-market-codes/L32030
710	2		_aSpringerLink (Online service)
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783319540627
776	0	8	_iPrinted edition: _z9783319540634
776	0	8	_iPrinted edition: _z9783319853079
856	4	0	_uhttps://doi.org/10.1007/978-3-319-54064-1
942			_2lcc _cBK