000			03539nam a22004695i 4500
999			_c2253 _d2253
001			978-3-319-60192-2
003			DE-He213
005			20200806150054.0
007			cr nn 008mamaa
008			170914s2017 gw | s |||| 0|eng d
020			_a9783319601922 (ebook)
020			_a9783319601915
024	7		_a10.1007/978-3-319-60192-2 _2doi
040			_aSpringer Nature Metadata _beng _cMIU _dMIU_ain
245	1	0	_aGenome Editing in Neurosciences / _cedited by Rudolf Jaenisch, Feng Zhang, Fred Gage.
250			_a1st ed. 2017.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aXI, 123 p. 16 illus. in color. _bonline resource.
490	1		_aResearch and Perspectives in Neurosciences, _x0945-6082
505	0		_aIntroduction -- In vitro modeling of complex neurological diseases -- Aquatic model organisms in neurosciences : the genome editing revolution -- Genome-wide genetic screening in the mammalian CNS -- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish -- Dissecting the role of synaptic proteins with CRISPR -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- Neuroscience research using non-human primate models and genome editing -- Multiscale genome engineering: Genome-wide screens and targeted approaches -- Using Genome Engineering to Understand Huntington’s Disease -- Therapeutic gene editing in muscles and muscle stem cells.
506	0		_aOpen Access
520			_aThis book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
650		0	_aHuman genetics.
650		0	_aNeurosciences.
650		0	_aBiomedical engineering.
650	1	4	_aHuman Genetics. _0https://scigraph.springernature.com/ontologies/product-market-codes/B12008
650	2	4	_aNeurosciences. _0https://scigraph.springernature.com/ontologies/product-market-codes/B18006
650	2	4	_aBiomedical Engineering/Biotechnology. _0https://scigraph.springernature.com/ontologies/product-market-codes/B24000
700	1		_aJaenisch, Rudolf. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aZhang, Feng. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGage, Fred. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783319601915
776	0	8	_iPrinted edition: _z9783319601939
776	0	8	_iPrinted edition: _z9783319868011
830		0	_aResearch and Perspectives in Neurosciences, _x0945-6082
856	4	0	_uhttps://doi.org/10.1007/978-3-319-60192-2
942			_2lcc _cBK