000			04738nam a22004335i 4500
999			_c2279 _d2279
001			978-1-4939-9074-0
003			DE-He213
005			20200910094049.0
007			cr nn 008mamaa
008			190705s2019 xxu| s |||| 0|eng d
020			_a9781493990740 (ebook)
020			_a9781493990733
024	7		_a10.1007/978-1-4939-9074-0 _2doi
040			_aSpringer Nature Metadata _beng _cMIU
050		4	_aQH447 _b.E96 2019
245	1	0	_aEvolutionary Genomics : _bStatistical and Computational Methods / _cedited by Maria Anisimova.
250			_a2nd ed. 2019.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Humana, _c2019.
300			_aXVII, 780 p. 189 illus., 110 illus. in color.
490	1		_aMethods in Molecular Biology, _x1064-3745 ; _v1910
505	0		_aIntroduction to Genome Biology and Diversity -- Probability, Statistics, and Computational Science -- A Not-So-Long Introduction to Computational Molecular Evolution -- Whole-Genome Alignment -- Inferring Orthology and Paralogy -- Transposable Elements and Their Identification -- Modern Phylogenomics: Building Phylogenetic Trees Using the Multispecies Coalescent Model -- Genome-Wide Comparative Analysis of Phylogenetic Trees: The Prokaryotic Forest of Life -- The Methodology Behind Network-Thinking: Graphs to Analyze Microbial Complexity and Evolution -- Bayesian Molecular Clock Dating Using Genome-Scale Datasets -- Genome Evolution in Outcrossing vs. Selfing vs. Asexual Species -- Selection Acting on Genomes -- Looking for Darwin in Genomic Sequences: Validity and Success Depends on the Relationship between Model and Data -- Evolution of Viral Genomes: Interplay between Selection, Recombination, and Other Forces -- Evolution of Protein Domain Architectures -- New Insights on the Evolution of Genome Content: Population Dynamics of Transposable Elements in Flies and Humans -- Association Mapping and Disease: Evolutionary Perspectives -- Ancestral Population Genomics -- Introduction to the Analysis of Environmental Sequences: Metagenomics with MEGAN -- Multiple Data Analyses and Statistical Approaches for Analyzing Data from Metagenomic Studies and Clinical Trials -- Systems Genetics for Evolutionary Studies -- Analyzing Epigenome Data in Context of Genome Evolution and Human Diseases -- Semantic Integration and Enrichment of Heterogeneous Biological Databases -- High-Performance Computing in Bayesian Phylogenetics and Phylodynamics Using BEAGLE -- Scalable Workflows and Reproducible Data Analysis for Genomics -- Sharing Programming Resources between Bio* Projects.
506	0		_aOpen Access
520			_aThis open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital relationships between genotype and phenotype. After a few educational primers, the book continues with sections on sequence homology and alignment, phylogenetic methods to study genome evolution, methodologies for evaluating selective pressures on genomic sequences as well as genomic evolution in light of protein domain architecture and transposable elements, population genomics and other omics, and discussions of current bottlenecks in handling and analyzing genomic data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that lead to the best results. Authoritative and comprehensive, Evolutionary Genomics: Statistical and Computational Methods, Second Edition aims to serve both novices in biology with strong statistics and computational skills, and molecular biologists with a good grasp of standard mathematical concepts, in moving this important field of study forward.
650		0	_aBioinformatics.
650		0	_aGenetics.
650		0	_aEvolutionary biology.
650	1	4	_aBioinformatics. _0https://scigraph.springernature.com/ontologies/product-market-codes/L15001
650	2	4	_aGenetics and Genomics. _0https://scigraph.springernature.com/ontologies/product-market-codes/L32000
650	2	4	_aEvolutionary Biology. _0https://scigraph.springernature.com/ontologies/product-market-codes/L21001
700	1		_aAnisimova, Maria. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9781493990733
776	0	8	_iPrinted edition: _z9781493990757
830		0	_aMethods in Molecular Biology, _x1064-3745 ; _v1910
856	4	0	_uhttps://doi.org/10.1007/978-1-4939-9074-0
942			_2lcc _cBK